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Know More About Antibodies

Antibodies are host proteins that are produced by the immune system in response to foreign molecules that enter the body. These foreign molecules are called antigens and the recognition of their molecules by the immune system leads to the production of selective antibodies capable of binding to specific antigens.

Antibodies are produced by B lymphocytes and circulate in the blood and lymph, where they bind to their specific antigens and thereby remove them from the circulation. You can also navigate to know more about antibodies.

The ability of the animal immune system to produce antibodies that can specifically bind to antigens can be used to construct probes to detect molecules of interest in a variety of research and diagnostic applications.

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Of course, no other technology currently exists that allows researchers to develop and manufacture highly specific molecular recognition tools. Several important properties, in addition to their high specificity, make antibodies very useful for development as probes.

For example, with the exception of the moieties that determine antigen binding, antibodies share a relatively uniform and well-characterized protein structure that allows them to be purified, labeled, and detected by predictable and reproducible general methods.

Methods for generating, purifying, and modifying antibodies for use as antigen-specific probes were developed in the 1970s and 1980s and have remained relatively unchanged since the publication of Classic Antibodies: A Laboratory Guide by Harlow and Lane in 1988.